Comparing therapeutic effects of Metformin and Pioglitazone in Polycystic ovary syndrome [PCOS]

To compare therapeutic effects of Metformin and Pioglitazone in Polycystic ovary syndrome [PCOS]. In a randomized clinical trial, 100 women with PCOS were recruited during a one year period in Al-Zahra Hospital of Tabriz. These patients were randomized into two groups of 50 patients receiving either Metformin 500 mg[TDS], or Pioglitazone 15 mg[BID], for six months. Clinical and laboratory findings were compared between the two groups at the baseline and end of the study. Pregnancy frequency was higher in Metformin group. Amelioration of menstrual cycles, hirsutism, and laboratory tests, including FBS, Hyperinsulinemia, oral glucose tolerance test, 2hpps and insulin, free testosterone and prolactin was significant in both groups. The change of serum total cholesterol and HDL was not significant in the Pioglitazone group. According to our results, Metformin is superior to Pioglitazone due to better influence on pregnancy and lipid profile

Hysteroscopy as a minimally invasive surgery, a good substitute for invasive gynecological procedures

Hysteroscopy is a safe and high efficient procedure so it is changing to a widespread procedure in dealing with many gynecologic and obstetrical conditions. This study aimed to evaluate the diagnostic and therapeutical efficiency of hysteroscopy in managing the common conditions including abnormal uterine bleeding, abortion and infertility. This was a descriptive cross-sectional study to compare hysteroscopy as a minimally invasive approach with conventional laparatomy and hysterectomy or repair of mulerian anomalies and watch the uterine cavity for intrauterine pathology in cases of infertility. Overall 277 women underwent hysteroscopy were evaluated in three groups: with AUB 226 cases, with infertility 34 cases and with recurrent abortions with septate uterus17 cases. The overall success rate was recorded and analyzed after six months in order of indication of hysteroscopy Hysteroscopy as sole diagnostic procedure in 16.5, 8.8 and 14.3%of AUB, infertility and abortion cases, respectively. In AUB cases, curettage, myomectomy, polypectomy and hysterectomy were the main diagnostic-therapeutical approaches along with hysteroscopy. In infertiles, myomectomy, polypectomy were the main diagnostic-therapeutical approaches In abortion group, laparoscopy guided, septum resection adhessiolysis, curettage and myomectomy were the main aproach. There was not any major complication. The diagnostic-therapeutically measures accompanying with the hysteroscopy were successful in 73.5% of the bleeding group and 33.3% of the infertility group in follow-up period. Based on our results, hysteroscopy is a safe, accurate and highly-efficient procedure in managing women with abnormal uterine bleeding, recurrent abortion due to septate uterus

Study on HLA-DQB1,03 allele associated with women human papilloma virus [HPV] lesions

The specific HLA alleles associated with HPV differ among various study groups. It has been suggested that women carrying HLA-DQw3 antigen encoded by DQB 103, are predisposed to develop cervical cancer. The aim of this study was to determine HLA-DQB103 alleles in HPV lesions. In a cross-sectional and analytical study, Hundred women enrolled into the study. Twenty of them had abnormal Pap smear, Fifty patients had condyloma lesions and 30 patients with malignant lesions. HLA-DQB03 and HPV infection was evaluated by PCR. PCR of HPV was positive in 50 women with condyloma lesions and 8 women with malignant lesion [p< 0.001]. HLA-DQB03 was positive in 9 women with abnormal Pap smear, 18 women with condyloma lesions and 7 women with malignant lesion[P= 0.261]. Positive PCR of HPV was significantly higher in women with condyloma lesions than other women [p< 0.001]. Mean age of patients with positive PCR of HPV was significantly lower than patients with negative PCR of HPV [P= 0.001]. Mean age of patients with positive HLA-DQB03 was 42.08 + 11.48 year and mean age of patients with negative HLA-DQB03 Was 43.83 +11.21 year [P= 0.462]. HLA-DQB03 was positive in 34% of patients. In this study, we do not see any significant correlation between HPV infection and HLA-DQB03 in the studied women